Targeting receptor tyrosine kinases in gastric cancer
نویسندگان
چکیده
منابع مشابه
Receptor tyrosine kinases: role in cancer progression
Tight control of cell proliferation and morphogenesis in conjunction with programmed cell death (apoptosis) is required to ensure normal tissue patterning. Alterations that cause an imbalance of the cellular signals that control these events may promote cell growth, suppress apoptosis, and enhance cell invasion, resulting in oncogenesis. Many of these signals are regulated by receptor tyrosine ...
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متن کاملUse of protein array to investigate receptor tyrosine kinases activated in gastric cancer.
Our study used protein array technology to analyze the expression status of various activated receptor tyrosine kinases (RTKs) in gastric carcinoma; then, we sought to discover an effective therapeutic receptor tyrosine kinase for this disease and investigated the anti-tumor mechanism of the therapeutic RTK. In addition to the expressions of activated RTKs in human gastric cancer and adjacent n...
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Articles should focus on tyrosine kinases in cancer and may include the following topics: Tyrosine kinases. § § Includes both tyrosine kinases and receptor tyrosine kinases, roles, including extracellular and intracellular signaling cascades. Aberrant tyrosine kinases § § Abnormalities including point mutations, chromosomal translocations and downstream effects of constitutive activation. Disea...
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ژورنال
عنوان ژورنال: World Journal of Gastroenterology
سال: 2014
ISSN: 1007-9327
DOI: 10.3748/wjg.v20.i16.4536